Kuvan 2017 U.S. PROMOTIONAL AUDIT REPORT

Published July 2018 • 21 Pages

The 5 Key Questions Addressed by this Report:

• How many physicians were reached by Kuvan through reportable promotional activity in 2017 to drive use within the Hyperphenylalaninemia market?
• What promotional mix was leveraged (e.g., sales rep detailing, physician education, and paid speaking) and what was the median spend on each type of activity?
• How does BioMarin’s depth of coverage vary within key specialties (e.g., Medical Genetics, Pediatric Medicine, Family Medicine, and Internal Medicine) and how does this compare to the overall set of rep-accessible physicians?
• How often are physicians receiving paid meals for Kuvan throughout the year (e.g., monthly, quarterly, annually)?
• Who were the most frequent meal recipients and top paid speakers for Kuvan in 2017?

Data Sources and Methodology:

• MDDetails leverages company-reported financial transaction data disclosed through CMS Open Payments. This data set captures all transfers of value (e.g., speaking fees, consulting fees, travel, education, and meals) made on behalf of a drug or device manufacturer to a physician. Currently, 42 months of longitudinal data is available – covering payments to more than 900,000 U.S. healthcare professionals.
• Over 200 paid interactions across 100 physicians made on behalf of Kuvan were carefully examined to support our analysis.