Xyrem 2021 U.S. PROMOTIONAL AUDIT REPORT

Published July 2022 • 34 Pages

The 5 Key Questions Addressed by this Report:

• How many physicians were reached by Xyrem through reportable promotional activity in 2021 and how does this compare to its peer set in the Cataplexy and Narcolepsy markets?
• What promotional mix was leveraged (e.g., sales rep detailing, physician education, and paid speaking) and what was the median spend on each type of activity?
• How does Jazz’s depth of coverage vary within key specialties (e.g., Nursing, Pulmonology, Neurology, Physician Assistant, Psychiatry, Family Medicine, Pediatric Medicine, Sleep Medicine, and Internal Medicine) and how does this compare to its peers and the overall set of rep-accessible physicians?
• How often are physicians receiving paid meals for Xyrem throughout the year (e.g., monthly, quarterly, annually)?
• Who were the most frequent meal recipients and top paid speakers for Xyrem in 2021?

Data Sources and Methodology:

• MDDetails leverages company-reported financial transaction data disclosed through CMS Open Payments. This data set captures all transfers of value (e.g., speaking fees, consulting fees, travel, education, and meals) made on behalf of a drug or device manufacturer to a physician. Currently, over 5 years of longitudinal data is available – covering payments to more than 1,000,000 U.S. healthcare professionals.
• Over 670 paid interactions across 420 physicians made on behalf of Xyrem were carefully examined to support our analysis. In addition, interaction data from 3 peer products (e.g. Sunosi, Wakix, and Xywav ) was leveraged to provide benchmarking and market insights.