Xpovio 2020 U.S. PROMOTIONAL AUDIT REPORT

Published July 2021 • 22 Pages

The 5 Key Questions Addressed by this Report:

• How many physicians were reached by Xpovio through reportable promotional activity in 2020 and how does this compare to its peer set in the Diffuse Large B-Cell Lymphoma, Multiple Myeloma, and Non-Hodgkin’s Lymphoma markets?
• What promotional mix was leveraged (e.g., sales rep detailing, physician education, and paid speaking) and what was the median spend on each type of activity?
• How does Karyopharm Therapeutics’s depth of coverage vary within key specialties (e.g., Hematology/Oncology, Medical Oncology, and Internal Medicine) and how does this compare to its peers and the overall set of rep-accessible physicians?
• How often are physicians receiving paid meals for Xpovio throughout the year (e.g., monthly, quarterly, annually)?
• Who were the most frequent meal recipients and top paid speakers for Xpovio in 2020?

Data Sources and Methodology:

• MDDetails leverages company-reported financial transaction data disclosed through CMS Open Payments. This data set captures all transfers of value (e.g., speaking fees, consulting fees, travel, education, and meals) made on behalf of a drug or device manufacturer to a physician. Currently, over 5 years of longitudinal data is available – covering payments to more than 1,000,000 U.S. healthcare professionals.
• Over 2,500 paid interactions across 1,600 physicians made on behalf of Xpovio were carefully examined to support our analysis. In addition, interaction data from 27 peer products (e.g. Adcetris, Aliqopa, Beleodaq, Bendeka, Blenrep, Calquence, Darzalex, Farydak, Folotyn, Gazyva, Imbruvica, Kymriah, Kyprolis, Monjuvi, Ninlaro, Polivy, Pomalyst, Revlimid, Ruxience, Sarclisa, Tazverik, Tecartus, Truxima, Venclexta, Xgeva, Yescarta, and Zevalin ) was leveraged to provide benchmarking and market insights.