Probuphine 2019 U.S. PROMOTIONAL AUDIT REPORT

Published July 2020 • 30 Pages

The 5 Key Questions Addressed by this Report:

• How many physicians were reached by Probuphine through reportable promotional activity in 2019 and how does this compare to its peer set in the Opioid Abuse market?
• What promotional mix was leveraged (e.g., sales rep detailing, physician education, and paid speaking) and what was the median spend on each type of activity?
• How does Titan’s depth of coverage vary within key specialties (e.g., Family Medicine, Anesthesiology, Internal Medicine, Addiction Medicine, Physical Medicine and Rehabilitation, Psychiatry, and Pain Medicine) and how does this compare to its peers and the overall set of rep-accessible physicians?
• How often are physicians receiving paid meals for Probuphine throughout the year (e.g., monthly, quarterly, annually)?
• Who were the most frequent meal recipients and top paid speakers for Probuphine in 2019?

Data Sources and Methodology:

• MDDetails leverages company-reported financial transaction data disclosed through CMS Open Payments. This data set captures all transfers of value (e.g., speaking fees, consulting fees, travel, education, and meals) made on behalf of a drug or device manufacturer to a physician. Currently, over 5 years of longitudinal data is available – covering payments to more than 1,000,000 U.S. healthcare professionals.
• Over 100 paid interactions across 100 physicians made on behalf of Probuphine were carefully examined to support our analysis. In addition, interaction data from 5 peer products (e.g. Bunavail, Lucemyra, Sublocade, Vivitrol, and Zubsolv ) was leveraged to provide benchmarking and market insights.