Cinryze 2020 U.S. PROMOTIONAL AUDIT REPORT

Published July 2021 • 21 Pages

The 5 Key Questions Addressed by this Report:

• How many physicians were reached by Cinryze through reportable promotional activity in 2020 and how does this compare to its peer set in the Hereditary Angioedema market?
• What promotional mix was leveraged (e.g., sales rep detailing, physician education, and paid speaking) and what was the median spend on each type of activity?
• How does Takeda’s depth of coverage vary within key specialties (e.g., Allergy/Immunology, Internal Medicine, and Pediatric Medicine) and how does this compare to its peers and the overall set of rep-accessible physicians?
• How often are physicians receiving paid meals for Cinryze throughout the year (e.g., monthly, quarterly, annually)?
• Who were the most frequent meal recipients and top paid speakers for Cinryze in 2020?

Data Sources and Methodology:

• MDDetails leverages company-reported financial transaction data disclosed through CMS Open Payments. This data set captures all transfers of value (e.g., speaking fees, consulting fees, travel, education, and meals) made on behalf of a drug or device manufacturer to a physician. Currently, over 5 years of longitudinal data is available – covering payments to more than 1,000,000 U.S. healthcare professionals.
• Over 300 paid interactions across 200 physicians made on behalf of Cinryze were carefully examined to support our analysis. In addition, interaction data from 4 peer products (e.g. Haegarda, Orladeyo, Ruconest, and Takhzyro ) was leveraged to provide benchmarking and market insights.