Zynrelef 2021 U.S. PROMOTIONAL AUDIT REPORT

Published July 2022 • 28 Pages

The 5 Key Questions Addressed by this Report:

• How many physicians were reached by Zynrelef through reportable promotional activity in 2021 and how does this compare to its peer set in the Pain – NSAIDS market?
• What promotional mix was leveraged (e.g., sales rep detailing, physician education, and paid speaking) and what was the median spend on each type of activity?
• How does Heron Therapeutics’s depth of coverage vary within key specialties (e.g., Orthopedic Surgery, Podiatry, Nursing, Anesthesiology, Physician Assistant, and General Surgery) and how does this compare to its peers and the overall set of rep-accessible physicians?
• How often are physicians receiving paid meals for Zynrelef throughout the year (e.g., monthly, quarterly, annually)?
• Who were the most frequent meal recipients and top paid speakers for Zynrelef in 2021?

Data Sources and Methodology:

• MDDetails leverages company-reported financial transaction data disclosed through CMS Open Payments. This data set captures all transfers of value (e.g., speaking fees, consulting fees, travel, education, and meals) made on behalf of a drug or device manufacturer to a physician. Currently, over 5 years of longitudinal data is available – covering payments to more than 1,000,000 U.S. healthcare professionals.
• Over 4,750 paid interactions across 3,740 physicians made on behalf of Zynrelef were carefully examined to support our analysis. In addition, interaction data from 5 peer products (e.g. Anjeso, Caldolor, Duexis, Pennsaid, and Xaracoll ) was leveraged to provide benchmarking and market insights.